The biomedical device market spans three scales: nano (DNA, protein, single molecule), micro (cell, organoid, tissue), and device (implant, diagnostic instrument). Our fabrication capabilities address all three.
Organ-on-Chip (OoC)
Multilayer PDMS chips with pneumatic Quake valves, peristaltic pumps, and thin flexible membranes replicate the microenvironment of human organs, lung, gut, kidney, brain, liver, and heart, for drug discovery and toxicity testing. PDMS soft lithography from SU-8 masters enables 3–5 day design-to-chip turnaround. COP injection-molded versions for production volumes where PDMS autofluorescence is a concern.
Micro-Electrode Arrays (MEA)
Planar and 3D MEA for extracellular neural signal recording, stimulation, and drug response monitoring. Pt or TiN electrode arrays on glass or Si substrate patterned by lift-off. SU-8 or polyimide passivation with electrode openings at recording sites. DRIE through-holes for 3D probe insertion. Biocompatible PI RDL for flexible implantable probe variants.
DNA Sequencing Flow Cells
Glass flow cells with NIL-defined nanopore arrays (<50nm) for nanopore sequencing, or precision microchannels for optical sequencing. Fusion or anodic bonding for hermetic glass-glass or glass-Si seals with no adhesive in the optical path. Large-format glass processing (500×600mm) enables 96-well or 384-well array formats at low cost-per-chip, critical for sequencing instrument economics.
LSPR Biosensors
Localised surface plasmon resonance chips with gold nanopillar or nanohole arrays on glass, fabricated by NIL and Au lift-off. The nanostructured gold surface is functionalised with antibodies, aptamers, or nucleic acid probes for label-free detection of cancer biomarkers, pathogen proteins, and nucleic acids. Sensitivity 10–100× higher than flat Au SPR chips due to localised field enhancement.
Drug Delivery Microdevices
Ni and Pd-Ni microneedle arrays by LIGA electroforming for transdermal drug delivery and interstitial fluid (ISF) sampling. Hollow microneedles with 1µm-diameter fluid channels. Droplet microfluidic chips for monodisperse microencapsulation of drug-loaded particles (CV <2%). Pd-Ni biocompatible grade for implant-contact applications.
Implantable Neural Interfaces
Neural probes and implantable sensors using biocompatible PI RDL and Au/Pt electrodes. Hermetic AuSn sealing for implantable optical transceivers (retinal implants, deep brain stimulators). ISO 10993-assessed polyimide for electrode passivation. NDA-protected, your implant design remains confidential from first technical discussion.
